Oncotarget: мезотелин с высокой цитотоксической активностью.

Oncotarget опубликовал « Двойную В- и Т-клеточную деиммунизацию рекомбинантного иммунотоксина, нацеленного на мезотелин с высокой цитотоксической активностью », в котором сообщалось, что рекомбинантные иммунотоксины - это генно-инженерные белки, разрабатываемые для лечения рака. Они состоят из Fv, нацеленного на раковый антиген, и части белкового токсина. Начиная с иммунотоксина, у которого подавлены В-клеточные эпитопы, авторы поэтапно добавляли мутации, которые подавляют Т-клеточные эпитопы. Конечный белок имеет значительно сниженную антигенность, что оценивается по связыванию с антисывороткой человека, и значительно сниженную способность активировать хелперные Т-клетки, оцененные в анализе активации Т-клеток. LMB-T14 вызывает полную ремиссию ксенотрансплантата рака, экспрессирующего мезотелин. Подход, использованный в этом исследовании Oncotarget, может быть использован для деиммунизации других терапевтических чужеродных белков.

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