Oncotarget: Ghrelin ameliorates tumor-induced adipose tissue atrophy and inflammation

 Oncotarget Volume 11, Issue 35 published "Ghrelin ameliorates tumor-induced adipose tissue atrophy and inflammation via Ghrelin receptor-dependent and -independent pathways" by Liu et. al which reported that Ghrelin has been proposed as a treatment for cancer cachexia partly by preventing AT atrophy.

This study characterizes the pathways involved in AT atrophy in the Lewis Lung Carcinoma -induced cachexia model and those mediating the effects of ghrelin in Ghsr / and Ghsr–/– mice.

Ghrelin administration prevented LLC-induced anorexia only in Ghsr /, but prevented WAT lipolysis, inflammation and atrophy in both genotypes, although its effects were greater in Ghsr /.

LLC-induced increases in BAT inflammation, WAT and BAT thermogenesis, and energy expenditure were not affected by ghrelin.

In conclusion, ghrelin ameliorates WAT inflammation, fat atrophy, and anorexia in LLC-induced cachexia.

Dr. Jose M. Garcia from The Veterans Affairs Puget Sound Health Care System, The University of Washington Department of Medicine, as well as The Baylor College of Medicine said, "Cachexia, defined as an involuntary loss of muscle and adipose tissue, is present in 15–65% of cancer patients depending on the tumor type, and it is strongly associated with poor outcomes."

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